Bold Mexican flavors, ice-cold margaritas, sizzling fajitas, and a lively cantina atmosphere right on Edmund Highway in Pelion, South Carolina.
Don Pepe Mexican Grill & Cantina has earned its reputation as the #1 restaurant in Pelion, South Carolina — rated 4.6 out of 5 across more than 1,100 reviews. Located at 7568 Edmund Highway, just before you reach Pelion's town limits on Hwy 302, Don Pepe is a well-run, community-loved restaurant that has been serving the area for many years.
Inside, you'll find a vibrant restaurant with a separate full cantina bar featuring TouchTunes, a big-screen TV, and a pool table. It's the kind of place perfect for a casual family dinner, a date night, or a lively group gathering. Weekly karaoke nights add an extra layer of fun that keeps regulars coming back.
The food speaks for itself: sizzling fajitas, a legendary triple quesadilla, fresh salsa with a spicy kick, and margaritas praised as the best in the area. Guests consistently highlight the fast, friendly service even during busy Friday and Saturday nights.
With over 1,100 verified reviews and a 4.6-star average, Don Pepe is Pelion's most loved dining destination — and it's easy to see why.
From the first chip and salsa to the last sip of a fresh margarita — every visit to Don Pepe is an experience worth repeating.
Guests consistently call it a must-try. One of the most-praised dishes on the menu — highly recommended for first-timers and regulars alike.
Fajitas Chicken, Camaron, Texanas, Monterrey, Don Pepe, and Hawaianas — each arriving sizzling hot at your table.
Guests who travel to Mexico compare Don Pepe's margaritas favorably. Fresh, balanced, and praised by locals as the best in the area.
The house hot sauce — the "good stuff in the back" — is regularly described as some of the best hot sauce guests have ever tried. One reviewer bought a pint to take home.
Camarones A La Diabla, Camarones Al Mojo De Ajo, El Cancun, Shrimp Coctel, Shrimp Enchiladas and more.
Even during peak Friday and Saturday nights, guests consistently report fast service and a staff that genuinely cares. "10/10, eat here!"
Weekly karaoke in the cantina bar area keeps the energy high. A great reason to make a night of it with friends or family.
A dedicated kids' menu, a welcoming atmosphere, and reasonable prices make Don Pepe a reliable choice for the whole family.
Over 1,100 verified reviews with a 4.6-star average. Here's what guests love about Don Pepe.
Was told to go here and have the triple quesadilla and man it was so good!! I highly recommend. Great food great service and all for a great price.
— Sir William Goes, April 2025I ordered the chicken fajitas and they were so delicious! Our server Andrea was phenomenal and quickly brought everything out and helped us have the best experience. 10/10, eat here!
— Keith Clemente, April 2025Came here on a Friday around 7PM and while it was a little busy, boy did they get our food out fast. Food was delicious, margarita was delicious. Salsa was spicier than normal — but I thought it was the best I've had.
— Joline Locklear, March 2025Amazing food, honestly some of the best Mexican I've ever had. House hot sauce — the good stuff in the back — is the best hot sauce hands down. I love my hot sauces. I bought a pint it was so good. Excited for the new location opening soon.
— Scott Wiggins, January 2025Don Pepe's is a great change from all of the chain Mexican places. They have really good menu choices and the best margaritas in town! I go to Mexico a few times a year and these are the best margaritas I have found!
— TripAdvisor ReviewerRestaurant is well-run and has been operating for many years. Serves Mexican food and has a separate bar with TouchTunes, big screen TV, and pool table. Great for lunch or dinner. Has weekly karaoke too.
— GL Hall, May 2025Monday–Tuesday: 11AM–9:30PM. Wednesday–Saturday: 11AM–10PM. Sunday: 11AM–9PM. Hours may occasionally vary — call (803) 894-0048 or check the Facebook page to confirm.
7568 Edmund Highway, Pelion, SC 29123 — on Hwy 302 just before Pelion's town limits. Easily accessible and well-known to locals throughout Lexington County.
Guests consistently recommend the Triple Quesadilla, Fajitas Don Pepe, Chicken Fajitas, and the house hot sauce (available in the cantina bar area). The fresh margaritas are also a must-try — praised as some of the best in the region.
Yes — there is a separate full cantina bar with TouchTunes, a big-screen TV, and a pool table. The bar area has its own atmosphere and is great for groups looking for a livelier experience.
Don Pepe hosts weekly karaoke nights. Check the Facebook page at @DonPepePelion for the current schedule.
Yes — takeout is available. Call ahead at (803) 894-0048 to place your order. You can also order online through the restaurant website at donpepepelion.com.
Yes — a new location on Edmund Highway (about 1 mile from the current location) opened in April/May 2025 with a Cinco de Mayo celebration. Reviews describe it as a beautiful brand new building. Follow their Facebook page for the latest updates.
| Mon – Tue | 11:00 AM – 9:30 PM |
| Wed – Sat | 11:00 AM – 10:00 PM |
| Sunday | 11:00 AM – 9:00 PM |